In the 1980s, CFS/ME used to be called "chronic Epstein-Barr virus syndrome" (CEBV) and "chronic mononucleosis" (EBV is the virus that causes mono). Later it was found that not all cases of CFS/ME are associated with EBV infection, but other herpesviruses may still be to blame.

Herpesviruses are a group of viruses that contains eight known human viruses. They can infect many parts of the human body, including the heart and the central nervous system. Unlike with most viruses, once they infect the body, they persist and cannot be eradicated. There are currently no vaccinations for them.

Most of the time the persistence of these viruses causes no symptoms, but sometimes they can reactivate, as people with HSV-1 and HSV-2 (oral and genital herpes) know all too well. Shingles is caused by reactivation of the varicella zoster virus (VZV), the virus that also causes chicken pox.

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